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To address the possible mechanism of the elevation of AQP5 abundance in IPR-administered animals, changes of AQP5 level in fasting animals, in which the exocytotic events are reduced, were examined.

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Endoscopic ultrasound revealed no underlying mass lesion. The up-regulated inflammatory genes in aging HSCs may have mechanistic implications for the decline of HSC function.

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Out of these, 22 genes were significantly up-regulated and 19 were significantly down-regulated.

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ADSP trials underwent WES at one of three NHGRI funded large-scale sequencing centers at Baylor, the Broad Institute, or Washington University.

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